Drug trafficking constitutes a major threat to public health and community well-being. Multi-jurisdictional drug task forces, comprised of law enforcement officers in one or more counties that agree to pool resources, were designed to combat drug distribution and trafficking. Researchers evaluated 19 drug task forces in Illinois using quantitative and qualitative methods. Quantitative methods included analyzing administrative data and state arrest records. Qualitative methods included focus groups with members of 18 task forces and surveys of both staff and policy board directors. The study revealed Illinois drug task forces made proportionately more drug arrests carrying more serious felony and manufacture/delivery charges than their local police counterparts. The study also showed the task forces fostered collaboration with stakeholders, maintained fidelity to critical elements of drug task forces, and garnered support from their policy boards.